Hyaluronic Acid (HA)

Hyaluronic Acid [Used]

It is a multifunctional and synergistic cosmetic complex composed of four distinct fractions and derivatives of Hyaluronic Acid (HA), enriched with Hydrolyzed Glycosaminoglycans (GAGs). It was developed to optimize three-dimensional hydration and mimic the endogenous architecture of the extracellular matrix (ECM).

Phytochemical Properties and Mechanisms of Action:

• Multi-Molecular Weight Hydrophilic Dynamics:
• Macromolecules (Sodium Hyaluronate Crosspolymer and Sodium Hyaluronate): Form an occlusive and viscoelastic polymeric network over the stratum corneum. They significantly reduce transepidermal water loss (TEWL) and provide superficial mechanical protection.
• Micromolecules (Hydrolyzed Hyaluronic Acid and Hydrolyzed GAGs): Exhibit high transdermal penetration capacity. They reach the viable layers of the epidermis and dermis, restoring hydric homeostasis and acting as cellular signaling agents for neocollagenesis.
• Fibrillar Stimulation and Dermal Remodeling: The crosspolymer technology provides resistance against early enzymatic degradation by hyaluronidases, prolonging thermal stability and the volumizing effect in the dermis. It promotes fibroblast activation to increase collagen and elastin synthesis.
• Barrier Repair and Keratinocyte Proliferation: Hydrolyzed GAGs accelerate re-epithelialization and tissue regeneration through the modulation of the cellular microenvironment, stimulating keratinocyte differentiation and reducing inflammatory mediators.
• Formulation Synergy and Bioavailability: Evens out the light refractive index in the epidermis through the swelling of the stratum corneum (soft-focus effect). It functions as an excellent carrier system for antioxidant transport.

Formulation and Safety Data:

• Toxicological Profile: Non-comedogenic, biocompatible, and hypoallergenic ingredient. Ideal for stabilizing aqueous systems (serums, lotions) and rejuvenating emulsions.
• Recommended Application Method: Incorporation into pH-controlled vehicles, and its final application should preferably occur on previously dampened skin to maximize the hydrogen binding coefficient.